Birdies on three of the final four holes saw Gary Woodland take a one-stroke lead at the OHL Tour Classic.
Two rounds without a single bogey saw Woodland move to the top of the leadboard at the Greg Norman-designed El Camaleon course, in Mexico, as he moved in front of fellow American Webb Simpson.
The 32-year-old – who won the last of his two PGA Tour titles in 2013 – carded a round of 64 on the second day to move to 13-under par.
"I haven't been here since my rookie year, so it's been since 2009," Woodland said.
"The golf course is in great shape. It sets up good for me.
“I can hit a lot of irons off the tees, lay back a little bit. The whole deal is to keep the ball in the fairway and then attack from there."
Scott Piercy lies behind second-placed Simpson on two-under, while overnight leader Chris Kirk was unable to build on his stunning opening round of 63.
Kirk carded a 70 to drop into joint fourth alongside Abraham Ancer, Russell Knox, Charles Howell III, Ben Martin, John Huh and Adam Hadwin.
Defending champion Graeme McDowell managed to make the cut after bouncing back from an awful opening day, but veteran American Jim Furyk was forced into a premature end to his first tournament of the new season.
But PGA Tour commissioner warns of consequences for players who ignore safety protocols.
McDowell has pulled out of the Travelers Championship.
The American was forced to withdraw from the Travelers Championship after the diagnosis during pre-tournament screening on Tuesday.
Brooks Koepka is looking to win a historic third successive title at the event.
Andrew Coltart reckons if the Ryder Cup can go ahead, it should go ahead.
Webb Simpson could hardly believe he emerged victorious after a “crazy day” at the RBC Heritage.
The American also won the Phoenix Open in February.
The Englishman shot eight-under 63 on day three of the event at Hilton Head, South Carolina.
McIlroy followed his second-round 65 with a five-under 66 to move to 10 under, three behind early clubhouse leader Joaquin Niemann.
Nick Watney became the first golfer to test positive for since the PGA Tour’s resumption.