Brian Stuard carded a second consecutive bogey-free round to take a one-shot lead at the rain-affected Zurich Classic.
Stuard, who is on 12-under, is followed by overnight leaders Jamie Lovemark and Jhonattan Vegas, who are in a tie for second on 11-under.
A plethora of golfers are in a tie for fourth on eight-under, including South Korea’s Byeong-Hun An.
World number one Jason Day is five strokes off the lead in a tie for 10th, while defending champion Justin Rose failed to make the cut.
Stuard, who is on the hunt for his first PGA Tour title, only managed to get through six holes, but made consecutive birdies at the seventh and eighth to record a four-under-par 68 in his second round and take the lead for only the second time in his career after 36 holes.
Lovemark and Vegas completed their second rounds on Friday and were unable to start their third rounds due to inclement weather conditions.
Day had only completed 10 holes prior to the start of play on Saturday and he went on to make a duo of birdies at the 11th and 13th to register a 68 in his second round and keep himself in contention.
Meanwhile, Rose carded his second consecutive round of 72 on Friday and subsequently missed the cut.
The tournament at Close House, scheduled to start on July 30, is set to be the first European Tour event since the coronavirus crisis halted action.
The world number one believes it would be the ‘right call’ to push the event back to 2021.
The exhibition match, against Phil Mickelson and Tom Brady, raised 20 million dollars.
The Dutchman finished third and second in the first two weeks of the home-based competition.
NFL stars Tom Brady and Peyton Manning will also be involved.
The US President was among the viewers watching the TaylorMade Driving Relief.
The US President phoned in as McIlroy played in a Sunday fundraiser for coronavirus victims.
Syme donated his prize money to charity.
‘This is the life of a caddie…’
The Northern Irishman is ranked number one in the world.