Rickie Fowler carded a four-under-par 68 to take a one-shot lead at the Wells Fargo Championship on Saturday.
Fowler, who is on nine-under, is followed by Roberto Castro in second place on eight-under.
James Hahn and Justin Rose are in a tie for third on seven-under, while defending champion Rory McIlroy is eight strokes adrift of the lead in a tie for 19th.
Fowler, whose last title came at the Deutsche Bank Championship in September last year, was in impressive form early on at Quail Hollow as he made two birdies on the front nine before kicking off the back nine with a birdie at the 10th.
While the world number five did make two bogeys over his next three holes, he bounced back with a hat-trick of birdies from the 14th to 16th, where he made a 27-foot putt.
Castro, who fired a 71, mirrored Fowler’s start as he too made a duo of birdies on the front nine. The 30-year-old, though, struggled a lot more on the back nine as he made two birdies and three bogeys. Despite this, he remains within touching distance of the 2012 champion.
Hahn surged up 10 places on the leaderboard after recording a 68, which consisted of six birdies and two bogeys, while Rose registered a 69, during which he made five birdies and two bogeys.
Meanwhile, McIlroy continued to climb up the leaderboard on Saturday even though he carded a 71. The world number three looked rusty at the beginning of the front nine as he started his round with two bogeys on his first four holes. While he did recover with two birdies, he faltered once again with a double bogey at the par-four ninth.
The Ulsterman enjoyed a much more successful back nine as he made three birdies, which included a stunning 79-foot putt at the 17th, and two bogeys.
The US President was among the viewers watching the TaylorMade Driving Relief.
The US President phoned in as McIlroy played in a Sunday fundraiser for coronavirus victims.
Syme donated his prize money to charity.
‘This is the life of a caddie…’
The Northern Irishman is ranked number one in the world.
Players entering the United States will face a 14-day quarantine period, while a strict testing regime will be in place at each tournament.
The experienced duo will be involved at Whistling Straits.
The world number 98 intends to split the 10,000 euros prize money between his own charity and a hospital in his native Rotterdam.
The biennial event between Europe and the United States is scheduled to take place from September 25-27.