Kevin Chappell is the new leader at the RSM Classic after shooting a five-under-par 70 on Friday.
Playing the Seaside Course, one of two courses being used this week, the American made four birdies and a bogey before holing a lengthy bunker shot for eagle at the 17th.
That took his total to 11 under par, following an opening six-under-par 66 at the Plantation course on Thursday.
Chappell, who has a top-three finish at the US Open but has never won a PGA Tour event, leads Sweden's Freddie Jacobson and overnight leader Kevin Kisner by a shot heading into Saturday's third round.
Jacobson shot a five-under 67 on the Plantation course, while Kisner had a three-under 67 at the Seaside course.
Kyle Stanley lies in fourth place a further shot back, while Jason Gore, Alex Cejka, Michael Kim and Hiroshi Iwata of Japan follow on eight under.
Graeme McDowell played the Plantation course in four-under-par 68 to move to seven under, four shots back.
Brandt Snedeker was set to miss the cut after a disappointing 74.
The US President was among the viewers watching the TaylorMade Driving Relief.
The US President phoned in as McIlroy played in a Sunday fundraiser for coronavirus victims.
Syme donated his prize money to charity.
‘This is the life of a caddie…’
The Northern Irishman is ranked number one in the world.
Players entering the United States will face a 14-day quarantine period, while a strict testing regime will be in place at each tournament.
The experienced duo will be involved at Whistling Straits.
The world number 98 intends to split the 10,000 euros prize money between his own charity and a hospital in his native Rotterdam.
The biennial event between Europe and the United States is scheduled to take place from September 25-27.